A study was made of the features of hemostatic disorders in patients with rheumatoid arthritis, depending on the activity and duration of the pathological process. It has been shown that changes in the hemostasis system with a tendency to hypercoagulability and thrombosis are formed in patients with rheumatoid arthritis against the background of inflammation, depending on the activity of the pathological process and the duration of the disease. Persons with the debut of rheumatoid arthritis, not exceeding 18 months from the onset of the first clinical manifestations, in the absence of disease-modifying therapy, have laboratory manifestations corresponding to the activation of the hemocoagulation cascade. Inflammation in active articular syndrome at the onset is characterized by an increase in the adhesive properties of platelets, hypercoagulability, thrombinemia, and a decrease in the reserves of the fibrinolytic system. The most important prognostic laboratory sign associated with the severity of inflammation in rheumatoid arthritis is thrombinemia.