ART, early pregnancy loss, risk factors


Summary. In women receiving assisted reproductive technology (ART), early miscarriage reduces initial success. However, risk factors for non-developing pregnancy have not been comprehensively studied. This study evaluates some potential risk factors for ART pregnancy. In this article, we have presented our findings on improving outcomes regarding early pregnancy loss after ART.
Relevance. The problem of protecting the health of mother and child is the most important component of public health and is of paramount importance for the formation of a healthy generation of people from the earliest period of their lives. One of the most important problems of practical obstetrics is miscarriage [2,5,9]. The frequency of miscarriage is 10-25% of all pregnancies, 5-10% are preterm births. Preterm infants account for over 50% of stillbirths, 70–80% of early neonatal mortality, and 60–70% of infant mortality [1,3,10]. Premature babies die 30-35 times more often than full-term babies, and perinatal mortality in miscarriage is 30-40 times higher than in term births.Despite a comprehensive study of the problem of infertility, insufficiently studied prognostic, therapeutic and preventive aspects of maintaining pregnancy and their complexity, as well as socio-economic factors, make this topic very relevant, requiring more in-depth study of clinical diagnostic, hormonal, and genetic aspects of this problem [ 4,6,7,8]. In assisted reproductive technology (ART), miscarriage prior to clinical detection by ultrasound scanning is also commonly referred to as biochemical pregnancy. Although studies conducted in the general population can provide some estimates of the risk of a miscarriage, the sample size in these studies has generally limited the statistical power to examine in detail potential risk factors for a miscarriage. Women receiving ART are regularly monitored for early detection of pregnancy by measuring serum hCG concentration on a specific day, usually 14–17 days after oocyte retrieval, equivalent to ovulation in the general population, and again by ultrasound scan approximately 6–7 weeks later . pregnancy. Thus, they represent an ideal population to study potential risk factors for miscarriage, and the results may be applicable to the general population.