Abstract
Gastroesophageal reflux disease is one of the most common diseases in modern medicine. A characteristic feature of this disease is that, along with the main symptoms (heartburn, pain behind the sternum and / or in the epigastric region), there may be secondary symptoms associated with impaired motility of the upper gastrointestinal tract, including the esophagus, and / or hypersensitivity stomach to distension (feeling of heaviness, fullness, bloating and rapid satiety in the epigastric region that occurs during or after eating), as well as extraesophageal (atypical) symptoms that aggravate the condition of patients with bronchopulmonary lesions, including asthma, as well as patients suffering from laryngitis, sinusitis and other ailments that worsen the quality of life. The article highlights the features of pathogenesis.