COVID-19 poses a serious threat to global public health. Currently, COVID-19 is considered as a systemic disease with impaired immune system function, affecting primarily the lungs, but also the heart, kidneys, intestines, liver and spleen. Liver damage occurs mainly in severe COVID-19. Today, it is not entirely clear whether changes in liver laboratory parameters in patients with COVID-19 are related to previously diagnosed liver disease, or whether they reflect liver damage in COVID-19. The article presents works devoted to the study of liver lesions during the period of COVID-19 disease in patients without previous pathology or with pre-existing liver pathology.