The investigation of hemostasiological disorders features has been carried out in patients with rheumatoid arthritis subject to the pathological process activity and duration. It has been shown that changes in the hemostasis system with tendency to the hypercoagulation and trombosis are formed in patients with rheumatoid arthritis against a background of inflammation depending on pathological process activity and disease duration. People with rheumatoid arthritis duration less than 18 months from the beginning of the first clinical presentations in absence of DMARDs, have laboratory evidences corresponding to hemocoagulative cascade activation. Inflammation under active articulate syndrome in onset is characterized by increase of platelets adhesion properties, hyper coagulation, thrombosis and decrease in fibrinolytic system reserves. Thrombinaemia is the most important prognostic laboratory characteristic associated with inflammation intensity at rheumatoid arthritis. The fibrinolysis reserves exhaustion, decrease in physiological anticoagulants level, thrombovasculitis maintenance are progressing with anamnesis duration, expressiveness of clinical and laboratory activity. Thrombocitosis and СRP high level contribute to this process. Decrease in plasma sanation capabilities does not allow effectively inhibiting hypercoagulation and reflects malignance of rheumatoid arthritis course.