Keywords
indole alkaloids, aorta, smooth muscle cells, relaxing effect, ion channels
Abstract
The article studied the relaxing effect of the indole alkaloids vincanine and pyrozoline on rat aorta preparations, and also showed the participation of the Na+/Ca2+ exchanger and voltage-dependent Ca2+ channels in the system. According to the results obtained, Na+ significantly reduces aortic contractions caused by Krebs solution and ouabain, vincanine and pyrozoline. Considering that these contractions of the aorta occur in the presence of Ca2+ ions coming directly through the Na+/Ca2+ exchange system, the action of the above alkaloids is associated with the Na+/Ca2+ exchange system.