One of the current problems of modern biology and medicine is the study of the state of the neuroendocrine system under various conditions. Numerous experimental and clinical observations have established that the neuroendocrine system undergoes significant changes during the individual development of the organism (B.V. Aleshin, F.Z. Meerson). In the adult body the development of adaptive reactions, in response to various influences (Petrov I.P., Boyko R.T.). Currently, the protection of the environmental health of the population is an urgent problem on a global scale. The predominant part of environmental pollutants are pesticides, without the use of which the prospective development of agriculture is impossible. According to the World Health Organization (WHO), between 500,000 and 2 million people worldwide are poisoned by pesticides each year, and 40,000 of these poisonings are fatal. The use of highly toxic organophosphorus or organochlorine pesticides is now banned or restricted and is being replaced by pesticides derived from pyrethroid, pyrazole and other classes. Their advantages are relatively low toxicity to animals and humans, high efficiency against insects when exposed to relatively small doses. It has been established that an important role in stress reactions caused by the action of damaging factors, in particular hypoxia, belongs to the cortical layer of the adrenal glands (V.N. Korostovtseva, I.D. Horizontov). The use of pesticides to increase crop yields on a global scale makes it extremely important to develop measures to prevent the negative effects of their effects on human and animal organisms.