Keywords
sphingolipids, sphingomyelin, ceramide, sphingosine, acid sphingomyelinase, neutral sphingomyelinase, oxidative stress, cytokines, neurodegeneration
Abstract
Being an essential component of plasma membrane, sphingolipids are bioactive lipids playing key roles in regulation of signaling. Compositions of sphingolipids, sphingolipid metabolism and its regulation in tissues, as well as involvement of sphingolipids in various pathological processes are analyzed in the review.