Keywords
Abstract
The aim of the study was to analyze the indicators of proinflammatory cytokines in patients with chronic obstructive pulmonary disease and concomitant coronary heart disease. Materials and methods of the study - 230 patients with exacerbation of chronic obstructive pulmonary disease were examined. The study included patients admitted to the pulmonology department with an exacerbation of COPD stage III with FEV1 < 50%. He underwent spirometry and ECG. Markers of inflammation in the blood (IL-6, C-RB, TNF-α) were studied upon admission to the hospital, after 10 days of treatment and 3 months after discharge of patients from the hospital.In the study group, patients receiving roflumilast had a decrease in TNF-α on average to normal figures.3 months after treatment in the control group, the level of TNF-α was normalized in 46.2% of patients, in the study group – in 84.5% of patients.