Keywords
Uromodulin, chronic kidney disease, glomerular filtration rate
Abstract
Uromodulin (Tamm-Horsfall protein; Umo; TCB) is a specific renal protein synthesized exclusively in the epithelial cells of the thick ascending loop of Henle and the initial section of the distal convoluted tubule. TCB is secreted predominantly into the lumen of the tubule and then enters the urine. A minor portion of uromodulin is secreted across the basolateral membrane into the renal interstitium and eventually enters the systemic circulation. This article discusses the importance of uromodulin in the early diagnosis of chronic kidney disease, changes in its amount in the blood and urine in cardiovascular diseases.