Keywords
acute leukemia, chromosomal translocations, prognosis, cytogenetics
Abstract
A study of significant genetic aberrations in a group of oncohematological patients in the city of Tashkent (Uzbekistan) was carried out using a standard cytogenetic study and an assessment of their role in the prognosis of the disease. The data obtained were compared with the effectiveness of polychemotherapy and prognostic groups were formed. In the group of poor prognosis, multiple genetic aberrations were more common, in contrast to the group of patients with a favorable prognosis of the disease, who predominantly had single genetic aberrations. A standard cytogenetic study allows you to simultaneously identify a wide range of genetic abnormalities to determine the prognosispatients with acute leukemia.