EFFECTS OF 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE ALKALOID ON CARDIOMYOCYTE NA+/CA2+ EXCHANGE UNDER NORMOXIA AND HYPOXIA CONDITIONS

Sadriddin N. Boboev; Inoyat Z. Zhumaev; Pulat B. Usmanov; Rustamov Sh. Yusubovich; Sherzod N. Zhuraqulov

Vol. 12 No. 3 (2023), Articles

Vol. 12 No. 3 (2023)

EFFECTS OF 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE ALKALOID ON CARDIOMYOCYTE NA+/CA2+ EXCHANGE UNDER NORMOXIA AND HYPOXIA CONDITIONS

Articles

Published 2023-10-20

Sadriddin N. Boboev
Inoyat Z. Zhumaev
Pulat B. Usmanov
Rustamov Sh. Yusubovich
Sherzod N. Zhuraqulov

Sadriddin N. Boboev

Inoyat Z. Zhumaev

Pulat B. Usmanov

Rustamov Sh. Yusubovich

Sherzod N. Zhuraqulov

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Keywords

papillary muscle, Na /Ca2 -exchange, Na /K -ATPase, isoquinoline alkaloid

Abstract

The purpose of this study is to evaluate the role of Na+/Ca2+-exchange in the cardioprotective properties of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (F-36) alkaloid. The alkaloid F-36 (from 5 μM to 100 μM) was found to have a positive inotropic effect on the contractile activity of the papillary muscle of the rat heart [1]. Positive inotropic effect of F-36 alkaloid was found to affect cardiomyocyte Na+/Ca2+-exchange and this was confirmed in experiments with NiCl2 and ouabain.

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