Abstract
From 2017 to 2019, the study included 82 patients with IBS who underwent examination and treatment in the gastroenterology department of the Bukhara Regional Multidisciplinary Medical Center. The average age of patients is 33.2 ±0.8 years. The level of dysbiosis in the refractory type of IBS is more clearly manifested than in the non-refractory type. With IBSr-d, dysbiosis of the 2nd degree was more pronounced than with IBSr-c. Dysbiosis of the 3rd degree was more often observed with refractory IBS than with nonrefractory IBS.