Abstract
Modern aspects of the pathogenesis of chronic recurrent herpetic stomatitis have been studied. It is indicated that the selected disease can be described as a chronic multi-link recurrent process with the characteristics of a combined secondary immunodeficiency with damage to the T- and B-links of immunity, oppression of the functional activity of NK cells and monocyte-macrophage cells, as well as damage to immune-controlling changes in the immune system. In any of the above cases, the herpes simplex virus has the possibility for persistence, mutation and, as a result, latency in the human body.