Synthesis and evaluation of the antioxidant activity of 1,2,4-triazole derivatives

Abstract

A series of 1,2,4-triazole scaffold containing alkoxy moiety was synthesized by stirring compounds 3a-b or 7a-e at room temperature with different acid chlorides including 4-methoxy benzoyl chloride or 3,4,5-trimethoxybenzoyl chloride. The structure of the prepared compounds was confirmed using different spectroscopic techniques such as IR, 1HNMR, 13CNMR, Mass spectra and high resolution mass or elemental analysis. The synthesized compounds examined for their antioxidant activity using DPPH radical scavenging activity. Results indicated that most of the tested compounds exhibited moderate antioxidant activity. Compound 8b exhibited remarkable antioxidant activity with SC50 of 49.4M compared to trolox as a reference antioxidant agent at 10µM concentration.