Keywords
Ocimum forskolei; Lamiaceae; Antiinflammatory; aqueous fraction
Abstract
The present study aimed to determine the lethal dose {LD50} using acute toxicity models and evaluate the anti-inflammatory activity of the total ethanolic extract (TEE) and different fractions of Ocimum forskolei Benth. aerial parts (leaves and stems) following the carrageenan-induced paw edema model in rats. The results obtained revealed that the LD50 value of the TEE was 8 g/kg body weight, while the extract and different fractions showed a significant decrease in paw edema, especially the aqueous fraction treated group with a % inhibition of (40.77 %, P < 0.001) in comparison with indomethacin (55.55 %, P < 0.001) as a standard.